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Common brand names

Single ingredient

No generic products are available.

Uses of Lotilaner

Lotilaner is a broad-spectrum insecticide and tickicide used to treat fleas and ticks on dogs and cats.

As the species of ticks controlled vary depending on the region, please check the label for parasites treated in your area.

Method of application

Oral application, supplied as chewable tablets.

Dosage and administration

Lotilaner is available as an oral treatment for dogs and cats, with dosage determined by your pet’s type and body weight. Please ensure you weigh your pet and only use the product intended for their species and size.

Chewable can be offered directly to your pet, added to food or placed directly in the animal’s mouth. Lotilaner must be administered to your pet with food or within 30 minutes of feeding.

A single dose of Lotilaner kills existing adult fleas and ticks and provides residual protection against newly emerged fleas and ticks for one month.

Treatment with Lotilaner can be started at any time of year and may be continued year-round without interruption.

Possible side effects

Side effects are rare, but adverse reactions reported in dogs treated with Lotilaner include weight loss, elevated blood urea nitrogen, excessive urination, and diarrhea.

Information on side effects in cats treated with Lotilaner has not been made available.


Do not use with dogs under 8 weeks of age or weighing less than 3 pounds (1.3 kg).

Do not use with cats under 8 weeks of age or weighing less than 1 pound (0.5 kg).

The safe use of Lotilaner with pregnant, breeding or lactating animals has not been established.

Use with caution in animals with a history of seizures or neurologic disorders. Seizures have been reported in animals treated with the isoxazoline family of drugs, which includes Lotilaner.

As parasites must feed on the host to become exposed to Lotilaner, the transmission of infectious parasite-borne diseases cannot be excluded.

Signs of toxicity

There is limited information available on Lotilaner toxicity.

If you suspect your dog or cat has had an overdose, please contact your veterinarian immediately.


This product does not require any special storage conditions.


This information is provided for general reference only and is not intended to replace the packaging label or veterinary advice. This page may not include all side effects, uses, brand names or applications.


Lotilaner drug information sheet
Lotilaner Information Sheet

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